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Adverse Events in Treating Smear-Positive Tuberculosis Patients in China

Author

Listed:
  • Tao Zhang

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

  • Jian Du

    (Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
    Beijing Chest Hospital, Capital Medical University, Beijing 101149, China)

  • Xiaoyan Yin

    (National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA 01702-5827, USA)

  • Fuzhong Xue

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

  • Yanxun Liu

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

  • Runzi Li

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

  • Cheng Luo

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

  • Liang Li

    (Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
    Beijing Chest Hospital, Capital Medical University, Beijing 101149, China)

  • Xiujun Li

    (Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China)

Abstract

This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3–23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5–11.1) and 6.3% (95% CI, 5.3–7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients’ knowledge on TB could reduce AE rate.

Suggested Citation

  • Tao Zhang & Jian Du & Xiaoyan Yin & Fuzhong Xue & Yanxun Liu & Runzi Li & Cheng Luo & Liang Li & Xiujun Li, 2015. "Adverse Events in Treating Smear-Positive Tuberculosis Patients in China," IJERPH, MDPI, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:13:y:2015:i:1:p:86-:d:61395
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