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Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

Author

Listed:
  • Seongil Jo

    (Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea
    These authors contributed equally to this work.)

  • Hae Dong Woo

    (Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea
    These authors contributed equally to this work.)

  • Ho-Jang Kwon

    (Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 330-714, Korea)

  • Se-Young Oh

    (Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul 130-701, Korea)

  • Jung-Duck Park

    (Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul 156-756, Korea)

  • Young-Seoub Hong

    (Department of Preventive Medicine and Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan 602-714, Korea)

  • Heesoo Pyo

    (Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 130-722, Korea)

  • Kyung Su Park

    (Advanced Analysis Center, Korea Institute of Science and Technology, Seoul 130-722, Korea)

  • Mina Ha

    (Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 330-714, Korea)

  • Ho Kim

    (Department of Epidemiology and Biostatistics, School of Public health, Seoul National University, Seoul 151-742, Korea)

  • Seok-Joon Sohn

    (Department of Preventive Medicine, College of Medicine, Chonnam National University, Gwangju 501-746, Korea)

  • Yu-Mi Kim

    (Department of Preventive Medicine and Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan 602-714, Korea)

  • Ji-Ae Lim

    (Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 330-714, Korea)

  • Sang-Ah Lee

    (Department of Preventive Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea)

  • Sang-Yong Eom

    (Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 362-763, Korea)

  • Byoung-Gwon Kim

    (Department of Preventive Medicine and Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan 602-714, Korea)

  • Kyoung-Mu Lee

    (Department of Environmental Health, Korea National Open University, Seoul 110-791, Korea
    These authors contributed equally to this work.)

  • Jong-Hyeon Lee

    (Institute of Environmental Safety and Protection, NeoEnBiz Co., Bucheon 420-130, Korea)

  • Myung Sil Hwang

    (Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Cheongwon 363-700, Korea)

  • Jeongseon Kim

    (Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea)

Abstract

Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.

Suggested Citation

  • Seongil Jo & Hae Dong Woo & Ho-Jang Kwon & Se-Young Oh & Jung-Duck Park & Young-Seoub Hong & Heesoo Pyo & Kyung Su Park & Mina Ha & Ho Kim & Seok-Joon Sohn & Yu-Mi Kim & Ji-Ae Lim & Sang-Ah Lee & Sang, 2015. "Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model," IJERPH, MDPI, vol. 12(8), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:8:p:9054-9067:d:53529
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    References listed on IDEAS

    as
    1. Ping Li & Xinbin Feng & Guangle Qiu, 2010. "Methylmercury Exposure and Health Effects from Rice and Fish Consumption: A Review," IJERPH, MDPI, vol. 7(6), pages 1-26, June.
    2. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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    Cited by:

    1. Kyle Dack & Matthew Fell & Caroline M. Taylor & Alexandra Havdahl & Sarah J. Lewis, 2022. "Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review," IJERPH, MDPI, vol. 19(4), pages 1-25, February.

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