IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i7p8198-8213d52705.html
   My bibliography  Save this article

Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults

Author

Listed:
  • Timothy C. Durazzo

    (Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, CA 94121, USA)

  • Dieter J. Meyerhoff

    (Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, CA 94121, USA)

  • Donna E. Murray

    (Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, CA 94121, USA)

Abstract

Chronic cigarette smoking is associated with numerous abnormalities in brain neurobiology, but few studies specifically investigated the chronic effects of smoking (compared to the acute effects of smoking, nicotine administration, or nicotine withdrawal) on cerebral perfusion ( i.e. , blood flow). Predominately middle-aged male (47 ± 11 years of age) smokers ( n = 34) and non-smokers ( n = 27) were compared on regional cortical perfusion measured by continuous arterial spin labeling magnetic resonance studies at 4 Tesla. Smokers showed significantly lower perfusion than non-smokers in the bilateral medial and lateral orbitofrontal cortices, bilateral inferior parietal lobules, bilateral superior temporal gyri, left posterior cingulate, right isthmus of cingulate, and right supramarginal gyrus. Greater lifetime duration of smoking (adjusted for age) was related to lower perfusion in multiple brain regions. The results indicated smokers showed significant perfusion deficits in anterior cortical regions implicated in the development, progression, and maintenance of all addictive disorders. Smokers concurrently demonstrated reduced blood flow in posterior brain regions that show morphological and metabolic aberrations as well as elevated beta amyloid deposition demonstrated by those with early stage Alzheimer disease. The findings provide additional novel evidence of the adverse effects of cigarette smoking on the human brain.

Suggested Citation

  • Timothy C. Durazzo & Dieter J. Meyerhoff & Donna E. Murray, 2015. "Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults," IJERPH, MDPI, vol. 12(7), pages 1-16, July.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:8198-8213:d:52705
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/7/8198/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/12/7/8198/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Timothy C. Durazzo & Dieter J. Meyerhoff & Sara Jo Nixon, 2010. "Chronic Cigarette Smoking: Implications for Neurocognition and Brain Neurobiology," IJERPH, MDPI, vol. 7(10), pages 1-32, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Meng-Chieh Chen & Chen-Feng Wang & Bo-Cheng Lai & Sun-Wung Hsieh & Szu-Chia Chen & Chih-Hsing Hung & Chao-Hung Kuo, 2021. "Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults," IJERPH, MDPI, vol. 18(1), pages 1-12, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:8198-8213:d:52705. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.