Author
Listed:
- Qinmei Xiong
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
These authors contributed equally to this work.)
- Xiao Liu
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
These authors contributed equally to this work.)
- Yang Shen
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Peng Yu
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Sisi Chen
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Jinzhu Hu
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Jianhua Yu
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Juxiang Li
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Hong-Sheng Wang
(Department of Pharmacology, College of Medicine, University of Cincinnati, Cincinnati, OH 2301, USA)
- Xiaoshu Cheng
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
- Kui Hong
(Department of Cardiovascular, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
The Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China)
Abstract
background: This study aimed to determine serum Bisphenol A (BPA) concentrations in patients with dilated cardiomyopathy (DCM) as well as the association between serum BPA and several hormonal parameters in DCM patients compared with a healthy control group. Materials and methods: Eighty-eight DCM patients and 88 age- and gender-matched healthy controls were included. Serum BPA levels and several hormonal parameters (including total testosterone (T), sex hormone-binding globulin (SHBG) and estradiol (E2) were measured by using corresponding ELISA Kits. The free androgen index (FAI) was calculated by the formula: total T in nmol/L × 100/SHBG in nmol/L. Results: BPA levels in the total DCM group were significantly higher compared with that in the controls (6.9 ± 2.7 ng/mL vs. 3.8 ± 1.9 ng/mL, p < 0.001). Significant difference was also observed in SHBG and FAI between DCM patients and controls, (76.9 ± 30.9 nM/L vs. 41.0 ± 15.6 nM/L and 2.9 ± 3.5 vs. 5.3 ± 2.6, respectively, both of p < 0.001). Similar trends were observed in the male and female subgroup. Mean T level was lower in DCM group than in control group (540.8 ± 186.0 pg/mL vs. 656.3 ± 112.9 pg/mL, p < 0.001). Linear regression analysis has shown that increasing serum BPA levels were statistically significantly associated with increased SHBG levels. However, no statistical difference was noted for E2. Conclusion: Our findings firstly demonstrated that BPA exposure increased in DCM patients compared with that in healthy controls, while FAI and T levels decreased. SHBG presented a positive association with BPA. It is concluded that hormone disorder induced by BPA exposure might be an environmental factor in the pathology of DCM.
Suggested Citation
Qinmei Xiong & Xiao Liu & Yang Shen & Peng Yu & Sisi Chen & Jinzhu Hu & Jianhua Yu & Juxiang Li & Hong-Sheng Wang & Xiaoshu Cheng & Kui Hong, 2015.
"Elevated Serum Bisphenol A Level in Patients with Dilated Cardiomyopathy,"
IJERPH, MDPI, vol. 12(5), pages 1-9, May.
Handle:
RePEc:gam:jijerp:v:12:y:2015:i:5:p:5329-5337:d:49760
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