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Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation

Author

Listed:
  • Cheryl Pirozzi

    (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA)

  • Anne Sturrock

    (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA)

  • Hsin-Yi Weng

    (Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA)

  • Tom Greene

    (Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, USA)

  • Mary Beth Scholand

    (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA)

  • Richard Kanner

    (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA)

  • Robert Paine III

    (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA)

Abstract

This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NO x ), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NO x in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.

Suggested Citation

  • Cheryl Pirozzi & Anne Sturrock & Hsin-Yi Weng & Tom Greene & Mary Beth Scholand & Richard Kanner & Robert Paine III, 2015. "Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation," IJERPH, MDPI, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:5:p:5061-5075:d:49434
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