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Monoamine Oxidase A Promoter Variable Number of Tandem Repeats ( MAOA-uVNTR ) in Alcoholics According to Lesch Typology

Author

Listed:
  • Agnieszka Samochowiec

    (Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland)

  • Magdalena Chęć

    (Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland)

  • Edyta Kopaczewska

    (University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland)

  • Jerzy Samochowiec

    (Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland)

  • Otto Lesch

    (Department of Psychiatry, Vienna University, Waehringer Guertel 18–20, A-1090 Vienna, Austria)

  • Elżbieta Grochans

    (Department of Nursing, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland)

  • Andrzej Jasiewicz

    (Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland)

  • Przemyslaw Bienkowski

    (Institute of Psychiatry and Neurology, Department of Pharmacology, Sobieskiego 9, 02-957 Warszawa, Poland)

  • Łukasz Kołodziej

    (Department of Orthopedics, Pomeranian Medical University, Unii Lubelskiej 1, 71-460 Szczecin, Poland)

  • Anna Grzywacz

    (Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland)

Abstract

Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy control subjects (n = 168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. Results: We found no association between alcohol dependence and MAOA gene polymorphism. Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

Suggested Citation

  • Agnieszka Samochowiec & Magdalena Chęć & Edyta Kopaczewska & Jerzy Samochowiec & Otto Lesch & Elżbieta Grochans & Andrzej Jasiewicz & Przemyslaw Bienkowski & Łukasz Kołodziej & Anna Grzywacz, 2015. "Monoamine Oxidase A Promoter Variable Number of Tandem Repeats ( MAOA-uVNTR ) in Alcoholics According to Lesch Typology," IJERPH, MDPI, vol. 12(3), pages 1-10, March.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:3:p:3317-3326:d:47032
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