IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i3p2612-2621d46195.html
   My bibliography  Save this article

Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities

Author

Listed:
  • Mattia Pedotti

    (Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland)

  • Valentina Elisabetta Viviana Ferrero

    (European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy)

  • Teresa Lettieri

    (European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy)

  • Pascal Colpo

    (European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy)

  • Stephane Follonier

    (CSEM Landquart, Bahnhofstrasse 1, Landquart 7302, Switzerland)

  • Luigi Calzolai

    (European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy)

  • Luca Varani

    (Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland)

Abstract

The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presence of EDCs. The opportunity to use either natural or rationally modified ER molecules is discussed. The latter approach was successfully applied in the EU-FP7 project RADAR, with the aim to develop a novel biosensor for the detection of organic pollutants both in the environment and in commercial water products.

Suggested Citation

  • Mattia Pedotti & Valentina Elisabetta Viviana Ferrero & Teresa Lettieri & Pascal Colpo & Stephane Follonier & Luigi Calzolai & Luca Varani, 2015. "Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities," IJERPH, MDPI, vol. 12(3), pages 1-10, February.
  • Handle: RePEc:gam:jijerp:v:12:y:2015:i:3:p:2612-2621:d:46195
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/3/2612/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/12/3/2612/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Stefania Marcheggiani & Roberto Spurio & Lucia Cimarelli & Duarte Tito & Laura Mancini, 2015. "Scientific Symposium “Small Solution for Big Water-Related Problems: Innovative Microarrays and Small Sensors to Cope with Water Quality and Food Security”," IJERPH, MDPI, vol. 12(12), pages 1-9, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:3:p:2612-2621:d:46195. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.