IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i1p1020-1028d44907.html
   My bibliography  Save this article

Could A Deletion in Neuraminidase Stalk Strengthen Human Tropism of the Novel Avian Influenza Virus H7N9 in China, 2013?

Author

Listed:
  • Liang Chen

    (Department of Sanitary Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
    Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
    These authors contributed equally to this work.)

  • Feng Zhu

    (Intensive Care Unit of Burn and Trauma Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    These authors contributed equally to this work.)

  • Chenglong Xiong

    (Department of Sanitary Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
    Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China)

  • Zhijie Zhang

    (Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
    Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai 200032, China
    These authors contributed equally to this work.)

  • Lufang Jiang

    (Department of Sanitary Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
    Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China)

  • Yue Chen

    (Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario K1H 8M5, Canada)

  • Genming Zhao

    (Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
    Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai 200032, China)

  • Qingwu Jiang

    (Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China)

Abstract

Objective. A novel avian influenza A virus (AIV) H7N9 subtype which emerged in China in 2013 caused worldwide concern. Deletion of amino-acids 69 to 73 in the neuraminidase stalk was its most notable characteristic. This study is aimed to discuss the tropism and virulence effects of this deletion. Methods : Neuraminidase gene sequences of N9 subtype were collected from NCBI and GISAID. MEGA6.0, Stata12.0, and UCSF Chimera were employed for sequence aligning, significance testing, and protein tertiary structure homology modeling. Results : A total of 736 sequences were obtained; there were 81 human isolates of the novel AIV H7N9, of which 79 had the deletion. Among all the 654 avian origin sequences, only 43 had the deletion ( p < 0.001). Tertiary structure displayed that the deletion obviously changed the spatial direction of neuraminidase. Conclusions : The deletion in neuraminidase stalk could have strengthened human tropism of the novel AIV H7N9, as well as its virulence.

Suggested Citation

  • Liang Chen & Feng Zhu & Chenglong Xiong & Zhijie Zhang & Lufang Jiang & Yue Chen & Genming Zhao & Qingwu Jiang, 2015. "Could A Deletion in Neuraminidase Stalk Strengthen Human Tropism of the Novel Avian Influenza Virus H7N9 in China, 2013?," IJERPH, MDPI, vol. 12(1), pages 1-9, January.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:1:p:1020-1028:d:44907
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/1/1020/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/12/1/1020/
    Download Restriction: no
    ---><---

    More about this item

    Keywords

    deletion; neuraminidase; H7N9; China;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:1:p:1020-1028:d:44907. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.