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Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model

Author

Listed:
  • Giuseppe Liotta

    (University of Tor Vergata, 18-00173 Rome, Italy)

  • Maria Cristina Marazzi

    (LUMSA University, 18-00173 Rome, Italy)

  • Khethimipilo E. Mothibi

    (Health Services Cluster, Cité du Djoué, P.O. Box 06 Brazzaville, South Africa)

  • Ines Zimba

    (Community of S.Egidio—DREAM program, Avenida de Julho 7, Maputo, Mozambique)

  • Evelyne E. Amangoua

    (Ministère de la Santé et de la lutte contre le SIDA, B.P. 2091, Abidjan, Ivory Coast)

  • Esther K. Bonje

    (Cameroon Baptist Convention Health Services, P.O. Box 1 Bamenda, Cameroon)

  • Bernard N. B. Bossiky

    (Programme National Multisectoriel de Lutte contre le Sida, Blvd Triomphal and 24 Novembre Kinshasa, Congo (RDC))

  • Precious A. Robinson

    (National Department of Health, Private Bag X9070, South Africa)

  • Paola Scarcella

    (University of Tor Vergata, 18-00173 Rome, Italy)

  • Kebby Musokotwane

    (Ministry of Health, Ndeke House, P.O. Box 30205, Lusaka, Zambia)

  • Leonardo Palombi

    (University of Tor Vergata, 18-00173 Rome, Italy)

  • Paola Germano

    (INMI L. Spallanzani, 00149 Rome, Italy)

  • Pasquale Narciso

    (INMI L. Spallanzani, 00149 Rome, Italy)

  • Andrea De Luca

    (Division of Infectious Diseases, Department of Medical Biotechnologies, University of Siena, Siena University Hospital, Siena 53100, Italy)

  • Elard Alumando

    (Community of S.Egidio—DREAM program, P.O. Box 30355, Blantyre, Malawi)

  • Sangare H. Mamary

    (Community of S.Egidio—DREAM program, P.O. Box 30355, Blantyre, Malawi)

  • Nurja A. Magid

    (Community of S.Egidio—DREAM program, Avenida de Julho 7, Maputo, Mozambique)

  • Giovanni Guidotti

    (Community of S.Egidio—DREAM program, Rome 00153, Italy)

  • Sandro Mancinelli

    (University of Tor Vergata, 18-00173 Rome, Italy)

  • Stefano Orlando

    (Community of S.Egidio—DREAM program, Rome 00153, Italy)

  • Marco Peroni

    (Community of S.Egidio—DREAM program, Rome 00153, Italy)

  • Ersilia Buonomo

    (University of Tor Vergata, 18-00173 Rome, Italy)

  • Karin Nielsen-Saines

    (David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA)

Abstract

The Drug Resource Enhancement against AIDS and Malnutrition Program (DREAM) gathered professionals in the field of Elimination of HIV-Mother-To-Child Transmission (EMTCT) in Maputo in 2013 to discuss obstacles and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa. During this workshop, the benefits of administrating combined antiretroviral therapy (cART) to HIV positive women from pregnancy throughout breastfeeding were reviewed. cART is capable of reducing vertical transmission to less than 5% at 24 months of age, as well as maternal mortality and infant mortality in both HIV infected and exposed populations to levels similar to those of uninfected individuals. The challenge for programs targeting eMTCT in developing countries is retention in care and treatment adherence. Both are intrinsically related to the model of care. The drop-out from eMTCT programs before cART initiation ranges from 33%–88% while retention rates at 18–24 months are less than 50%. Comprehensive strategies including peer-to-peer education, social support and laboratory monitoring can reduce refusals to less than 5% and attain retention rates approaching 90%. Several components of the model of care for reduction of HIV-1 MTCT are feasible and implementable in scale-up strategies. A review of this model of care for HIV eMTCT is provided.

Suggested Citation

  • Giuseppe Liotta & Maria Cristina Marazzi & Khethimipilo E. Mothibi & Ines Zimba & Evelyne E. Amangoua & Esther K. Bonje & Bernard N. B. Bossiky & Precious A. Robinson & Paola Scarcella & Kebby Musokot, 2015. "Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model," IJERPH, MDPI, vol. 12(10), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:10:p:13224-13239:d:57486
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    References listed on IDEAS

    as
    1. Ersilia Buonomo & Simona De Luca & Dyna Tembo & Paola Scarcella & Paola Germano & Anna Maria Doro Altan & Leonardo Palombi & Giuseppe Liotta & Karin Nielsen-Saines & Fulvio Erba & Maria Cristina Maraz, 2012. "Nutritional Rehabilitation of HIV-Exposed Infants in Malawi: Results from the Drug Resources Enhancement Against AIDS and Malnutrition Program," IJERPH, MDPI, vol. 9(2), pages 1-14, January.
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    Cited by:

    1. Massimo Leone & Fausto Ciccacci & Stefano Orlando & Sandro Petrolati & Giovanni Guidotti & Noorjehan Abdul Majid & Victor Tamba Tolno & JeanBaptiste Sagno & Darlington Thole & Fabio Massimo Corsi & Mi, 2021. "Pandemics and Burden of Stroke and Epilepsy in Sub-Saharan Africa: Experience from a Longstanding Health Programme," IJERPH, MDPI, vol. 18(5), pages 1-19, March.

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      Keywords

      elimination of HIV MTCT; DREAM program;

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