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Association of Exposure to Particular Matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

Author

Listed:
  • Xiaole Liu

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

  • Hui Lian

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

  • Yanping Ruan

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

  • Ruijuan Liang

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

  • Xiaoyi Zhao

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

  • Michael Routledge

    (Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK)

  • Zhongjie Fan

    (Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)

Abstract

Background : Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM 2.5 and PM 10 have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT). Methods : Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI). The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. Results : Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 μg/m 3 in PM 2.5 and PM 10 were associated with an increase of CIMT (16.79 μm; 95% CI, 4.95–28.63 μm and 4.13 μm; 95% CI, −5.79–14.04 μm, respectively). Results shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. Conclusions : Exposure to PM 2.5 had a significant association with CIMT and for women the effect may be more obvious.

Suggested Citation

  • Xiaole Liu & Hui Lian & Yanping Ruan & Ruijuan Liang & Xiaoyi Zhao & Michael Routledge & Zhongjie Fan, 2015. "Association of Exposure to Particular Matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 12(10), pages 1-17, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:10:p:12924-12940:d:57189
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    Cited by:

    1. Alberto Izzotti & Paola Spatera & Zumama Khalid & Alessandra Pulliero, 2022. "Importance of Punctual Monitoring to Evaluate the Health Effects of Airborne Particulate Matter," IJERPH, MDPI, vol. 19(17), pages 1-18, August.

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