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Urinary 1-Hydroxypyrene is Associated with Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction

Author

Listed:
  • Fernando Freitas

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Post-graduate Program of Pharmacy Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Natália Brucker

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil)

  • Juliano Durgante

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Guilherme Bubols

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Rachel Bulcão

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Angela Moro

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Department of Clinical and Toxicological Analysis, University of Caxias do Sul, Caxias do Sul, RS 95070-560, Brazil)

  • Mariele Charão

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Post-graduate Program of Pharmacy Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Marília Baierle

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Post-graduate Program of Pharmacy Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Sabrina Nascimento

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Post-graduate Program of Pharmacy Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Bruna Gauer

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Elisa Sauer

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil)

  • Marcelo Zimmer

    (Toxicology Institute, Pharmacy Faculty, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil)

  • Flávia Thiesen

    (Toxicology Institute, Pharmacy Faculty, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil)

  • Iran Castro

    (Institute of Cardiology, University Cardiology Foundation, Porto Alegre, RS 90620-000, Brazil)

  • Paulo Saldiva

    (Department of Pathology, College of Medicine, University of São Paulo, São Paulo, SP 05508-070, Brazil)

  • Solange C. Garcia

    (Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Post-graduate Program of Pharmacy Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
    Institute of Cardiology, University Cardiology Foundation, Porto Alegre, RS 90620-000, Brazil)

Abstract

Several studies have associated exposure to environmental pollutants, especially polycyclic aromatic hydrocarbons (PAHs), with the development of cardiovascular diseases. Considering that 1-hydroxypyrene (1-OHP) is the major biomarker of exposure to pyrenes, the purpose of this study was to evaluate the potential association between 1-OHP and oxidative stress/inflammatory biomarkers in patients who had suffered an acute myocardial infarction (AMI). After adopting the exclusion criteria, 58 post-infarction patients and 41 controls were sub-divided into smokers and non-smokers. Urinary 1-OHP, hematological and biochemical parameters, oxidative stress biomarkers (MDA, SOD, CAT, GPx and exogenous antioxidants) and the inflammatory biomarker (hs-CRP) were analyzed. 1-OHP levels were increased in post-infarct patients compared to controls ( p < 0.05) and were correlated to MDA ( r = 0.426, p < 0.01), CAT ( r = 0.474, p < 0.001) and β-carotene ( r = −0.309; p < 0.05) in non-smokers. Furthermore, post-infarction patients had elevated hs-CRP, MDA, CAT and GPx levels compared to controls for both smokers and non-smokers. Besides, β-carotene levels and SOD activity were decreased in post-infarction patients. In summary, our findings indicate that the exposure to pyrenes was associated to lipid damage and alterations of endogenous and exogenous antioxidants, demonstrating that PAHs contribute to oxidative stress and are associated to acute myocardial infarction.

Suggested Citation

  • Fernando Freitas & Natália Brucker & Juliano Durgante & Guilherme Bubols & Rachel Bulcão & Angela Moro & Mariele Charão & Marília Baierle & Sabrina Nascimento & Bruna Gauer & Elisa Sauer & Marcelo Zim, 2014. "Urinary 1-Hydroxypyrene is Associated with Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction," IJERPH, MDPI, vol. 11(9), pages 1-14, September.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:9:p:9024-9037:d:39808
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