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Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn

Author

Listed:
  • Xi Peng

    (College of Veterinary Medicine, Sichuan Agricultural University, Sichuan 625014, China)

  • Keying Zhang

    (Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan 625014, China)

  • Shiping Bai

    (Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan 625014, China)

  • Xuemei Ding

    (Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan 625014, China)

  • Qiufeng Zeng

    (Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan 625014, China)

  • Jun Yang

    (Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan 625014, China)

  • Jing Fang

    (College of Veterinary Medicine, Sichuan Agricultural University, Sichuan 625014, China)

  • Kejie Chen

    (College of Veterinary Medicine, Sichuan Agricultural University, Sichuan 625014, China)

Abstract

The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups with six replicates per group and 30 birds per replicate. The experiment lasted for 6 weeks and the five dietary treatments consisted of control, 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The histopathological spleen lesions from the contaminated corn groups was characterized as congestion of red pulp, increased necrotic cells and vacuoles in the splenic corpuscle and periarterial lymphatic sheath. The contaminated corn intake significantly increased relative weight of spleen, percentages of apoptotic splenocytes, induced cell cycle arrest of splenocytes, increased the percentages of CD3 + CD8 + T cells and decreased the ratios of CD3 + CD4 + to CD3 + CD8 + . The results suggest that AFB-induced immunosuppression maybe closely related to the lesions of spleen.

Suggested Citation

  • Xi Peng & Keying Zhang & Shiping Bai & Xuemei Ding & Qiufeng Zeng & Jun Yang & Jing Fang & Kejie Chen, 2014. "Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn," IJERPH, MDPI, vol. 11(8), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:8567-8580:d:39396
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    Cited by:

    1. Xi Peng & Shiping Bai & Xuemei Ding & Keying Zhang, 2017. "Pathological Impairment, Cell Cycle Arrest and Apoptosis of Thymus and Bursa of Fabricius Induced by Aflatoxin-Contaminated Corn in Broilers," IJERPH, MDPI, vol. 14(1), pages 1-11, January.

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