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Atopic Diseases and Systemic Lupus Erythematosus: An Epidemiological Study of the Risks and Correlations

Author

Listed:
  • Yu-Ping Hsiao

    (Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dermatology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to this work.)

  • Jeng-Dau Tsai

    (Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to this work.)

  • Chih-Hsin Muo

    (Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung 404, Taiwan
    Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan)

  • Chung-Hung Tsai

    (Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan)

  • Fung-Chang Sung

    (Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung 404, Taiwan
    Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan)

  • Ya-Tang Liao

    (Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan)

  • Yen-Jung Chang

    (Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei 106, Taiwan
    These authors contributed equally to this work.)

  • Jen-Hung Yang

    (School of Medicine, Tzu Chi University, and Department of Dermatology, Buddhist Tzu Chi General Hospital, Hualien 907, Taiwan
    These authors contributed equally to this work.)

Abstract

Both atopic diseases and systemic lupus erythematosus (SLE) are immune disorders that may lead to physical complications or multi-system comorbidities. This population-based case-control study was designed to evaluate the risk of SLE associated with atopic diseases. Using a national insurance claims dataset in Taiwan, we identified 1673 patients newly diagnosed with SLE and 6692 randomly selected controls frequency matched for gender, age and index date. The odds ratios (OR) for SLE were calculated for associations with allergic rhinitis, allergic conjunctivitis, atopic dermatitis and asthma. The SLE patients were predominantly female (82.5%) with a mean age of 40.1 (SD = 18.2). The patients with SLE had a higher rate of atopic dermatitis (6.81% vs. 3.06%), and asthma (10.6% vs. 7.64%) was approximately 2 times more common in the patients with lupus than in those without. The patients with atopic disease (atopic dermatitis, allergic rhinitis, allergic conjunctivitis and asthma) were at a significant risk for SLE. The overall risk for SLE increased as the number of atopic diseases increased from 1.46 to 2.29, compared with—individuals without the diseases ( p < 0.0001). In conclusion, this population-based case-control study demonstrates a significant relationship between atopic diseases and the risk of SLE, especially for females. Atopic dermatitis plays a stronger role than other types of atopic disease in association with SLE.

Suggested Citation

  • Yu-Ping Hsiao & Jeng-Dau Tsai & Chih-Hsin Muo & Chung-Hung Tsai & Fung-Chang Sung & Ya-Tang Liao & Yen-Jung Chang & Jen-Hung Yang, 2014. "Atopic Diseases and Systemic Lupus Erythematosus: An Epidemiological Study of the Risks and Correlations," IJERPH, MDPI, vol. 11(8), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:8112-8122:d:38994
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