IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v11y2014i8p7841-7855d38908.html
   My bibliography  Save this article

Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice

Author

Listed:
  • Xiakun Zhang

    (School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China)

  • Jing Lu

    (Computer Science Department, Oklahoma State University, 219 MSCS, Stillwater, OK 74078, USA)

  • Shuyu Zhang

    (Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, China Meteorological Administration, 2070 Donggang East Road, Lanzhou 730020, China)

  • Chunling Wang

    (School of Applied Meteorology, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China)

  • Baojian Wang

    (Lanzhou Central Meteorological Observatory, 2070 Donggang East Road, Lanzhou 730020, China)

  • Pinwen Guo

    (School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China)

  • Lina Dong

    (School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China)

Abstract

The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter.

Suggested Citation

  • Xiakun Zhang & Jing Lu & Shuyu Zhang & Chunling Wang & Baojian Wang & Pinwen Guo & Lina Dong, 2014. "Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice," IJERPH, MDPI, vol. 11(8), pages 1-15, August.
  • Handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:7841-7855:d:38908
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/11/8/7841/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/11/8/7841/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Anna Alberini & Will Gans & Mustapha Alhassan, 2011. "Individual and Public-Program Adaptation: Coping with Heat Waves in Five Cities in Canada," IJERPH, MDPI, vol. 8(12), pages 1-23, December.
    2. Chunling Wang & Shuyu Zhang & Ying Tian & Baojian Wang & Shuanghe Shen, 2014. "Effects of Simulated Heat Waves on ApoE-/- Mice," IJERPH, MDPI, vol. 11(2), pages 1-8, January.
    3. J. L. Ble-Castillo & G. Cleva-Villanueva & J. C. Díaz-Zagoya & R. Medina-Santillán & H. O. Rubio-Arias & J. D. Méndez, 2007. "Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women," IJERPH, MDPI, vol. 4(4), pages 1-8, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. McKenzie H. Tilstra & Ishwar Tiwari & Leigh Niwa & Sandra Campbell & Charlene C. Nielsen & C. Allyson Jones & Alvaro Osornio Vargas & Okan Bulut & Bernadette Quemerais & Jordana Salma & Kyle Whitfield, 2021. "Risk and Resilience: How Is the Health of Older Adults and Immigrant People Living in Canada Impacted by Climate- and Air Pollution-Related Exposures?," IJERPH, MDPI, vol. 18(20), pages 1-22, October.
    2. Kaddour Mehiriz & Pierre Gosselin & Isabelle Tardif & Marc-André Lemieux, 2018. "The Effect of an Automated Phone Warning and Health Advisory System on Adaptation to High Heat Episodes and Health Services Use in Vulnerable Groups—Evidence from a Randomized Controlled Study," IJERPH, MDPI, vol. 15(8), pages 1-13, July.
    3. Milan Ščasný & Anna Alberini, 2012. "Valuation of Mortality Risk Attributable to Climate Change: Investigating the Effect of Survey Administration Modes on a VSL," IJERPH, MDPI, vol. 9(12), pages 1-22, December.
    4. Diane Bélanger & Pierre Gosselin & Pierre Valois & Belkacem Abdous, 2014. "Perceived Adverse Health Effects of Heat and Their Determinants in Deprived Neighbourhoods: A Cross-Sectional Survey of Nine Cities in Canada," IJERPH, MDPI, vol. 11(11), pages 1-26, October.

    More about this item

    Keywords

    heat wave weather; senile mice; HSP60; SOD; TNF; sICAM-1; atherosclerosis;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:7841-7855:d:38908. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.