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Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China

Author

Listed:
  • Qiang Zhang

    (Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China)

  • Yongfang Li

    (Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China)

  • Juan Liu

    (Library of Tianjin Medical University, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China)

  • Da Wang

    (Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China)

  • Quanmei Zheng

    (Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China)

  • Guifan Sun

    (Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China)

Abstract

Incomplete arsenic (As) methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The percentage of each As species (iAs%, MMA%, and DMA%), the primary methylation index (PMI) and secondary methylation index (SMI) were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs (99.08 vs. 70.63 μg/g Cr, p = 0.006) and MMA (69.34 vs. 42.85 μg/g Cr, p = 0.016) than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% (15.49 vs. 12.11, p = 0.036) and SMI (0.74 vs. 0.81, p = 0.025) were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions.

Suggested Citation

  • Qiang Zhang & Yongfang Li & Juan Liu & Da Wang & Quanmei Zheng & Guifan Sun, 2014. "Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China," IJERPH, MDPI, vol. 11(7), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:7:p:7319-7332:d:38277
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    Citations

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    Cited by:

    1. Yongfang Li & Da Wang & Xin Li & Quanmei Zheng & Guifan Sun, 2015. "A Potential Synergy between Incomplete Arsenic Methylation Capacity and Demographic Characteristics on the Risk of Hypertension: Findings from a Cross-Sectional Study in an Arsenic-Endemic Area of Inn," IJERPH, MDPI, vol. 12(4), pages 1-18, March.
    2. Elisa Bustaffa & Francesca Gorini & Fabrizio Bianchi & Fabrizio Minichilli, 2020. "Factors Affecting Arsenic Methylation in Contaminated Italian Areas," IJERPH, MDPI, vol. 17(14), pages 1-21, July.
    3. Hui Shen & Qiang Niu & Mengchuan Xu & Dongsheng Rui & Shangzhi Xu & Gangling Feng & Yusong Ding & Shugang Li & Mingxia Jing, 2016. "Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 13(2), pages 1-18, February.
    4. Fabrizio Minichilli & Fabrizio Bianchi & Anna Maria Ronchi & Francesca Gorini & Elisa Bustaffa, 2018. "Urinary Arsenic in Human Samples from Areas Characterized by Natural or Anthropogenic Pollution in Italy," IJERPH, MDPI, vol. 15(2), pages 1-19, February.

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