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Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention

Author

Listed:
  • Natasa Rajkovic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Miroslava Zamaklar

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Katarina Lalic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Aleksandra Jotic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Ljiljana Lukic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Tanja Milicic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Sandra Singh

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Ljubica Stosic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

  • Nebojsa M. Lalic

    (Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia)

Abstract

This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m 2 ) (group A), 21 overweight (25 kg/m 2 ≤ BMI < 30 kg/m 2 ) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin.

Suggested Citation

  • Natasa Rajkovic & Miroslava Zamaklar & Katarina Lalic & Aleksandra Jotic & Ljiljana Lukic & Tanja Milicic & Sandra Singh & Ljubica Stosic & Nebojsa M. Lalic, 2014. "Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention," IJERPH, MDPI, vol. 11(4), pages 1-17, April.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:4:p:4049-4065:d:35057
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