IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v11y2014i4p3661-3677d34668.html
   My bibliography  Save this article

A Biomarker Found in Cadmium Exposed Residents of Thailand by Metabolome Analysis

Author

Listed:
  • Dhitiwass Suvagandha

    (Environmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Muneko Nishijo

    (Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan)

  • Witaya Swaddiwudhipong

    (Mae Sot General Hospital, Mae Sot District, Tak 63110, Thailand)

  • Ruymon Honda

    (Department of Nursing, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan)

  • Morimasa Ohse

    (Japan Clinical Metabolomics Institute, Kahoku, Ishikawa 929-1174, Japan)

  • Tomiko Kuhara

    (Japan Clinical Metabolomics Institute, Kahoku, Ishikawa 929-1174, Japan)

  • Hideaki Nakagawa

    (Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan)

  • Werawan Ruangyuttikarn

    (Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

Abstract

First, the urinary metabolic profiling by gas chromatography-mass spectrometry (GC-MS), was performed to compare ten cadmium (Cd) toxicosis cases from a Cd-polluted area in Mae Sot (Thailand) with gender-matched healthy controls. Orthogonal partial list square-discrimination analysis was used to identify new biomarker candidates in highly Cd exposed toxicosis cases with remarkable renal tubular dysfunction. The results of the first step of this study showed that urinary citrate was a negative marker and myo -inositol was a positive marker for Cd toxicosis in Thailand. In the second step, we measured urinary citrate in the residents (168 Cd-exposed subjects and 100 controls) and found significantly lower levels of urinary citrate and higher ratios of calcium/citrate and magnesium/citrate, which are risk factors for nephrolithiasis, in highly Cd-exposed residents. Additionally, this inverse association of urinary citrate with urinary Cd was observed after adjustment for age, smoking and renal tubular dysfunction, suggesting a direct effect of Cd on citrate metabolism. These results indicate that urinary citrate is a useful biomarker for the adverse health effects of Cd exposure in a Thai population with a high prevalence of nephrolithiasis.

Suggested Citation

  • Dhitiwass Suvagandha & Muneko Nishijo & Witaya Swaddiwudhipong & Ruymon Honda & Morimasa Ohse & Tomiko Kuhara & Hideaki Nakagawa & Werawan Ruangyuttikarn, 2014. "A Biomarker Found in Cadmium Exposed Residents of Thailand by Metabolome Analysis," IJERPH, MDPI, vol. 11(4), pages 1-17, April.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:4:p:3661-3677:d:34668
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/11/4/3661/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/11/4/3661/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:11:y:2014:i:4:p:3661-3677:d:34668. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.