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Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study

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  • Hui-Chen Lin

    (Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Fifth Branch office, Centers for Disease Control, Ministry of Health and Welfare, Kaohsiung 813, Taiwan)

  • Hui-Fen Chiu

    (Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Shu-Chen Ho

    (Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Chun-Yuh Yang

    (Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Division of Environmental Health and Occupational Medicine, National Health Research Institute, Miaoli 350, Taiwan)

Abstract

The aim of this study was to investigate the effect of influenza vaccination (and annual revaccination) on the risk of stroke admissions. We conducted a population-based case-control study in Taiwan. Cases consisted of patients >65 years of age who had a first-time diagnosis of stroke during the influenza seasons from 2006 to 2009. Controls were selected by matching age, sex, and index date to cases. Multiple logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Ever vaccinated individuals in the current vaccination season were associated with a reduced risk of ischemic stroke admissions (OR = 0.76, 95% CI = 0.60–0.97). Compared with individuals never vaccinated against influenza during the past 5 years, the adjusted ORs were 0.92 (95% CI = 0.68–1.23) for the group with 1 or 2 vaccinations, 0.73 (95% CI = 0.54–1.00) for the group with 3 or 4 vaccinations, and 0.56 (95% CI = 0.38–0.83) for the group with 5 vaccinations. There was a significant trend of decreasing risk of ischemic stroke admissions with an increasing number of vaccinations. This study provides evidence that vaccination against influenza may reduce the risk of hospitalization for ischemic stroke and that annual revaccination provides greater protection.

Suggested Citation

  • Hui-Chen Lin & Hui-Fen Chiu & Shu-Chen Ho & Chun-Yuh Yang, 2014. "Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study," IJERPH, MDPI, vol. 11(4), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:4:p:3639-3649:d:34661
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    References listed on IDEAS

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    1. Arden, N. & Monto, A.S. & Ohmit, S.E., 1995. "Vaccine use and the risk of outbreaks in a sample of nursing homes during an influenza epidemic," American Journal of Public Health, American Public Health Association, vol. 85(3), pages 399-401.
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    Cited by:

    1. Hye Jung Yang & Sung-il Cho, 2014. "Influenza Vaccination Coverage among Adults in Korea: 2008–2009 to 2011–2012 Seasons," IJERPH, MDPI, vol. 11(12), pages 1-12, November.

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