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Neurotoxicity of Acrylamide in Exposed Workers

Author

Listed:
  • Manuela Pennisi

    (Department of Chemistry, University of Catania, Catania 95123, Italy)

  • Giulia Malaguarnera

    (International Ph.D. Programme in Neuropharmacology, University of Catania, Catania 95123, Italy)

  • Valentina Puglisi

    (Department of Neurosciences, University of Catania, Catania 95123, Italy)

  • Luisa Vinciguerra

    (Department of Neurosciences, University of Catania, Catania 95123, Italy)

  • Marco Vacante

    (Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania 95126, Italy)

  • Mariano Malaguarnera

    (Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania 95126, Italy)

Abstract

Acrylamide (ACR) is a water-soluble chemical used in different industrial and laboratory processes. ACR monomer is neurotoxic in humans and laboratory animals. Subchronic exposure to this chemical causes neuropathies, hands and feet numbness, gait abnormalities, muscle weakness, ataxia, skin and in some cases, cerebellar alterations. ACR neurotoxicity involves mostly the peripheral but also the central nervous system, because of damage to the nerve terminal through membrane fusion mechanisms and tubulovescicular alterations. Nevertheless, the exact action mechanism is not completely elucidated. In this paper we have reviewed the current literature on its neurotoxicity connected to work-related ACR exposure. We have analyzed not only the different pathogenetic hypotheses focusing on possible neuropathological targets, but also the critical behavior of ACR poisoning. In addition we have evaluated the ACR-exposed workers case studies. Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies.

Suggested Citation

  • Manuela Pennisi & Giulia Malaguarnera & Valentina Puglisi & Luisa Vinciguerra & Marco Vacante & Mariano Malaguarnera, 2013. "Neurotoxicity of Acrylamide in Exposed Workers," IJERPH, MDPI, vol. 10(9), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:9:p:3843-3854:d:28305
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