IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v10y2013i11p5737-5749d30104.html
   My bibliography  Save this article

Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort

Author

Listed:
  • Hye Ah Lee

    (Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Young Ju Kim

    (Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Hwayoung Lee

    (Department of Anatomy, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Hye Sun Gwak

    (Colleage of Pharmacy, Ewha Womans University, Seoul 120-750, Korea)

  • Eun Ae Park

    (Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Su Jin Cho

    (Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Hae Soon Kim

    (Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Eun Hee Ha

    (Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

  • Hyesook Park

    (Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)

Abstract

To assess the effect of urinary bisphenol A (BPA) on repeated measurements of androgenic hormones and metabolic indices, we used multivariate analysis of variance (MANOVA) adjusted for potential confounders at baseline. During July to August 2011, 80 preadolescent girls enrolled in the Ewha Birth & Growth Cohort study participated in a follow-up study and then forty-eight of them (60.0%) came back one year later. Baseline levels of estradiol and androstenedione were higher in the BPA group than in the non-BPA group. One year later, girls in the high BPA exposure group showed higher levels of androstenedione, testosterone, estradiol, and insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index, than those in the other groups ( p < 0.05). In MANOVA, estradiol and androstenedione showed significant differences among groups, while dehydroepiandrosterone, insulin, and HOMA-IR showed marginally significant differences. Exposure to BPA may affect endocrine metabolism in preadolescents. However, further investigation is required to elucidate the mechanisms linking BPA with regulation of androgenic hormones.

Suggested Citation

  • Hye Ah Lee & Young Ju Kim & Hwayoung Lee & Hye Sun Gwak & Eun Ae Park & Su Jin Cho & Hae Soon Kim & Eun Hee Ha & Hyesook Park, 2013. "Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort," IJERPH, MDPI, vol. 10(11), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:11:p:5737-5749:d:30104
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/10/11/5737/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/10/11/5737/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ka Young Kim & Eunil Lee & Yanghee Kim, 2019. "The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis," IJERPH, MDPI, vol. 16(14), pages 1-9, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:10:y:2013:i:11:p:5737-5749:d:30104. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.