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Antimicrobial Effect of 7- O -Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

Author

Listed:
  • Sun Hee Moon

    (Department of Animal Science, Iowa State University, Ames 50011, USA
    Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea)

  • Jae Hoon Lee

    (Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea)

  • Kee-Tae Kim

    (Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea)

  • Yong-Sun Park

    (Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea
    Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea
    Department of Chemistry, Konkuk University, Seoul 143-701, Korea)

  • Seung-Yeol Nah

    (Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea
    Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea
    Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea)

  • Dong Uk Ahn

    (Department of Animal Science, Iowa State University, Ames 50011, USA
    Department of Animal Science and Technology, Sunchon National University, Sunchon 540-742, Korea)

  • Hyun-Dong Paik

    (Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea
    Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea)

Abstract

The antimicrobial effect of a novel flavonoid (7- O -butylnaringenin) on Helicobacter pylori 26695, 51, and SS1 strains and its inhibitory effect on the urease activity of the strains were evaluated and compared with those of several natural flavonoids. First, various flavonoids were screened for antimicrobial activities using the paper disc diffusion method. Hesperetin and naringenin showed the strongest antimicrobial effects among the natural flavonoids tested, and thus hesperetin and naringenin were selected for comparison with 7- O -butylnaringenin. The antimicrobial effect of 7- O -butylnaringenin was greater than that of the hesperetin and naringenin. H. pylori 51 was more sensitive to 7- O -butylnaringenin (2 log reduction of colony forming units, p < 0.05) than the other two strains at 200 μM. 7- O -Butylnaringenin also showed the highest inhibitory effect against urease activity of H. pylori . Morphological changes of H. pylori 26695 treated with these flavonoids indicated that both hesperetin and 7- O -butylnaringenin at 200 μM damaged the cell membranes.

Suggested Citation

  • Sun Hee Moon & Jae Hoon Lee & Kee-Tae Kim & Yong-Sun Park & Seung-Yeol Nah & Dong Uk Ahn & Hyun-Dong Paik, 2013. "Antimicrobial Effect of 7- O -Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains," IJERPH, MDPI, vol. 10(11), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:11:p:5459-5469:d:29949
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