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Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review

Author

Listed:
  • Leena Rivina

    (Department of Environmental Health Sciences, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA)

  • Robert Schiestl

    (Department of Environmental Health Sciences, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA
    JCCC Healthy and At-Risk Populations Program Area, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA
    Department of Radiation Oncology, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA)

Abstract

As the number of cancer survivors treated with radiation as a part of their therapy regimen is constantly increasing, so is concern about radiation-induced cancers. This increases the need for therapeutic and mitigating agents against secondary neoplasias. Development and efficacy testing of these agents requires not only extensive in vitro assessment, but also a set of reliable animal models of radiation-induced carcinogenesis. The laboratory mouse ( Mus musculus ) remains one of the best animal model systems for cancer research due to its molecular and physiological similarities to man, small size, ease of breeding in captivity and a fully sequenced genome. This work reviews relevant M. musculus inbred and F 1 hybrid animal models and methodologies of induction of radiation-induced leukemia, thymic lymphoma, breast, and lung cancer in these models. Where available, the associated molecular pathologies are also included.

Suggested Citation

  • Leena Rivina & Robert Schiestl, 2012. "Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review," IJERPH, MDPI, vol. 10(1), pages 1-37, December.
    • Handle: RePEc:gam:jijerp:v:10:y:2012:i:1:p:107-143:d:22454
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