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RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury

Author

Listed:
  • Christine M. Hale

    (College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Kyle J. Beauchemin

    (College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Courtney L. Brann

    (College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Julie K. Moulton

    (College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Ramaz Geguchadze

    (College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Benjamin J. Harrison

    (College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

  • Geoffrey K. Ganter

    (College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA)

Abstract

To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drososophila larvae and those of uninjured larvae. Third-instar larvae expressing a green fluorescent protein (GFP)-tagged ribosomal subunit specifically in Class 4 dendritic arborization neurons, recognized as pickpocket-expressing primary nociceptors, via the GAL4/UAS method, were injured by ultraviolet light or sham-injured. Larvae were subjected to translating ribosome affinity purification for the GFP tag and nociceptor-specific ribosome-bound RNA was sequenced.

Suggested Citation

  • Christine M. Hale & Kyle J. Beauchemin & Courtney L. Brann & Julie K. Moulton & Ramaz Geguchadze & Benjamin J. Harrison & Geoffrey K. Ganter, 2025. "RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury," Data, MDPI, vol. 10(2), pages 1-7, January.
    • Handle: RePEc:gam:jdataj:v:10:y:2025:i:2:p:11-:d:1572469
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