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Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale

Author

Listed:
  • Jéssica Pires Farias

    (Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Ministro Reis Velloso, Universidade Federal do Delta do Parnaíba, Parnaíba 64202-020, Brazil)

  • Ana Luisa Alves Nogueira Barros

    (Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, Faculdade de Medicina, Campus DarcyRibeiro, Universidade de Brasília, Brasília 70910-900, Brazil
    Programa de Pós-graduação em Medicina Tropical, Núcleo de Medicina Tropical, Faculdade de Medicina, Campus Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil)

  • Alyne Rodrigues de Araújo-Nobre

    (Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Ministro Reis Velloso, Universidade Federal do Delta do Parnaíba, Parnaíba 64202-020, Brazil)

  • Enoque Pereira Costa Sobrinho-Júnior

    (Laboratório de Atividade Antileishmania, Núcleo de Pesquisas em Plantas Medicinais, Campus Ministro Petrônio Portella, Universidade Federal do Piauí, Ininga, Teresina 64049-550, Brazil)

  • Michel Muálem de Moraes Alves

    (Laboratório de Atividade Antileishmania, Núcleo de Pesquisas em Plantas Medicinais, Campus Ministro Petrônio Portella, Universidade Federal do Piauí, Ininga, Teresina 64049-550, Brazil)

  • Fernando Aécio de Amorim Carvalho

    (Laboratório de Atividade Antileishmania, Núcleo de Pesquisas em Plantas Medicinais, Campus Ministro Petrônio Portella, Universidade Federal do Piauí, Ininga, Teresina 64049-550, Brazil)

  • Klinger Antonio da Franca Rodrigues

    (Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Ministro Reis Velloso, Universidade Federal do Delta do Parnaíba, Parnaíba 64202-020, Brazil)

  • Ivanilza Moreira de Andrade

    (Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Ministro Reis Velloso, Universidade Federal do Delta do Parnaíba, Parnaíba 64202-020, Brazil)

  • Francisco Artur e Silva-Filho

    (Programa de Pós-graduação em Química, Universidade Estadual do Piauí, Parnaíba 64002-150, Brazil)

  • Daniel Carneiro Moreira

    (Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, Faculdade de Medicina, Campus DarcyRibeiro, Universidade de Brasília, Brasília 70910-900, Brazil)

  • David Fernandes Lima

    (Faculdade de Medicina, Universidade Federal do Vale do São Francisco, Paulo Afonso 48605-560, Brazil)

  • Massimo Lucarini

    (CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy)

  • Alessandra Durazzo

    (CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy)

  • Daniel Dias Rufino Arcanjo

    (Laboratório de Atividade Antileishmania, Núcleo de Pesquisas em Plantas Medicinais, Campus Ministro Petrônio Portella, Universidade Federal do Piauí, Ininga, Teresina 64049-550, Brazil
    Laboratório de Estudos Funcionais e Moleculares em Fisiofarmacologia, LAFMOL, Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, Teresina 64049-550, Brazil)

  • José Roberto de Souza de Almeida Leite

    (Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Campus Ministro Reis Velloso, Universidade Federal do Delta do Parnaíba, Parnaíba 64202-020, Brazil
    Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, Faculdade de Medicina, Campus DarcyRibeiro, Universidade de Brasília, Brasília 70910-900, Brazil
    Programa de Pós-graduação em Medicina Tropical, Núcleo de Medicina Tropical, Faculdade de Medicina, Campus Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil)

Abstract

Considering the therapeutic potential of Varronia curassavica Jacq. essential oil and the great value in the pharmaceutical market, this study aims to evaluate the influence of plant age on the chemical composition and biological activities of V. curassavica Jacq. essential oil. The plant age is a parameter that can influence the chemical composition of the essential oil, as well as its pharmacological potential. For this purpose, essential oils from aerial parts of V. curassavica produced at different ages (4, 10, 14 and 18 months-age) were used. According to chromatograms obtained by GC-MS, the essential oils were mainly composed of α-pinene, trans -caryophyllene, α-santalene, alloaromadendrene and α-humulene. The chemical composition of V. curassavica essential oils varied qualitatively and quantitatively with the aging of the plants, and the essential oils from plants at 18 month-age appeared to be the most distinct from the others. The tested essential oil samples showed inhibitory activity against Candida albicans (MIC = 1000 µg/mL) but did not show antibacterial activity against the tested bacteria. The cytotoxic activity levels against the murine macrophages varied among the oils extracted from the plants at different ages; the IC 50 values of the essential oils increased with age (171.90 µg/mL at 18 month-age). More studies should be carried out to assess whether age also affects the therapeutic effects of essential oils, resulting in the manufacture of plant-derived formulations that balance production costs, toxicity and therapeutic effects.

Suggested Citation

  • Jéssica Pires Farias & Ana Luisa Alves Nogueira Barros & Alyne Rodrigues de Araújo-Nobre & Enoque Pereira Costa Sobrinho-Júnior & Michel Muálem de Moraes Alves & Fernando Aécio de Amorim Carvalho & Kl, 2023. "Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale," Agriculture, MDPI, vol. 13(2), pages 1-13, February.
    • Handle: RePEc:gam:jagris:v:13:y:2023:i:2:p:373-:d:1057321
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