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The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

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  • Qinyue Lu

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China
    These authors contributed equally to this work.)

  • Weicheng Zong

    (College of Veterinary Medcine, Yangzhou University, Yangzhou 225009, China
    These authors contributed equally to this work.)

  • Mingyixing Zhang

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

  • Zhi Chen

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

  • Zhangping Yang

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

Abstract

Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.

Suggested Citation

  • Qinyue Lu & Weicheng Zong & Mingyixing Zhang & Zhi Chen & Zhangping Yang, 2022. "The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation," Agriculture, MDPI, vol. 12(7), pages 1-21, June.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:7:p:947-:d:852618
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    References listed on IDEAS

    as
    1. Ayumu Sugiura & Sevan Mattie & Julien Prudent & Heidi M. McBride, 2017. "Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes," Nature, Nature, vol. 542(7640), pages 251-254, February.
    2. Jinuk Kong & Yul Ji & Yong Geun Jeon & Ji Seul Han & Kyung Hee Han & Jung Hyun Lee & Gung Lee & Hagoon Jang & Sung Sik Choe & Myriam Baes & Jae Bum Kim, 2020. "Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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