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Selection, recombination, and the ancestral initiation graph

Author

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  • Alberti, Frederic
  • Herrmann, Carolin
  • Baake, Ellen

Abstract

Recently, the selection–recombination equation with a single selected site and an arbitrary number of neutral sites was solved by Alberti and Baake (2021) by means of the ancestral selection–recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection–recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.

Suggested Citation

  • Alberti, Frederic & Herrmann, Carolin & Baake, Ellen, 2021. "Selection, recombination, and the ancestral initiation graph," Theoretical Population Biology, Elsevier, vol. 142(C), pages 46-56.
    • Handle: RePEc:eee:thpobi:v:142:y:2021:i:c:p:46-56
    DOI: 10.1016/j.tpb.2021.08.001
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