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Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains

Author

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  • Kitayimbwa, J.M.
  • Mugisha, J.Y.T.
  • Saenz, R.A.

Abstract

One of the serious threats facing the administration of antiretroviral therapy to human immunodeficiency virus (HIV-1) infected patients is the reported increasing prevalence of transmitted drug resistance. However, given that HIV-1 drug-resistant strains are often less fit than the wild-type strains, it is expected that drug-resistant strains that are present during the primary phase of the HIV-1 infection are replaced by the fitter wild-type strains. This replacement of HIV-1 resistant mutations involves the emergence of wild-type strains by a process of backward mutation. How quickly the replacement happens is dependent on the class of HIV-1 mutation group.

Suggested Citation

  • Kitayimbwa, J.M. & Mugisha, J.Y.T. & Saenz, R.A., 2016. "Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains," Theoretical Population Biology, Elsevier, vol. 112(C), pages 33-42.
    • Handle: RePEc:eee:thpobi:v:112:y:2016:i:c:p:33-42
    DOI: 10.1016/j.tpb.2016.08.001
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