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Translational science and the hidden research system in universities and academic hospitals: A case study

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  • Lander, Bryn
  • Atkinson-Grosjean, Janet

Abstract

Innovation systems (IS) and science policy scholarship predominantly focus on linkages between universities and industry, and the commercial translation of academic discoveries. Overlooked in such analyses are important connections between universities and academic hospitals, and the non-commercial aspects of translational science. The two types of institutions tend to be collapsed into a single entity--'the university'--and relational flows are lost. Yet the distinctions and flows between the two are crucial elements of translational science and the biomedical innovation system. This paper explores what has been called the 'hidden research system' that connects hospitals, universities, and their resources, with the clinical and scientific actors who make the linkages possible. Then, using a novel conceptual model of translational science, we examine the individual interactions and dynamics involved in a particular example of the biomedical innovation system at work: the diagnosis of IRAK-4 deficiency, a rare immunological disorder, and the translational flows that result. Contra to conventional IS analyses, we are able to point to the strong role of public-sector institutions, and the weak role of the private-sector, in the translational processes described here. Our research was conducted within a Canadian network of scientists and clinician-scientists studying the pathogenomics of immunological disorders and innate immunity.

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  • Lander, Bryn & Atkinson-Grosjean, Janet, 2011. "Translational science and the hidden research system in universities and academic hospitals: A case study," Social Science & Medicine, Elsevier, vol. 72(4), pages 537-544, February.
    • Handle: RePEc:eee:socmed:v:72:y:2011:i:4:p:537-544
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    References listed on IDEAS

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    Cited by:

    1. M. Teresa Antonio-García & Irene López-Navarro & Jesús Rey-Rocha, 2014. "Determinants of success for biomedical researchers: a perception-based study in a health science research environment," Scientometrics, Springer;Akadémiai Kiadó, vol. 101(3), pages 1747-1779, December.
    2. Ellen Siu, 2018. "Interorganisational collaboration in Academic Health Science Centre: A case study on King’s Health Partnership," Working Papers 40, Birkbeck Centre for Innovation Management Research, revised Feb 2021.
    3. Au, Larry, 2021. "Recent scientific/intellectual movements in biomedicine," Social Science & Medicine, Elsevier, vol. 278(C).
    4. Lander, Bryn, 2016. "Boundary-spanning in academic healthcare organisations," Research Policy, Elsevier, vol. 45(8), pages 1524-1533.
    5. Jesús Rey-Rocha & Irene López-Navarro & M. Teresa Antonio-García, 2015. "Opening doors to basic-clinical collaboration and translational research will improve researchers’ performance," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(3), pages 2057-2069, December.
    6. Taran Thune & Magnus Gulbrandsen, 2016. "Combining knowledge to generate new ideas. A study of disclosed ideas for life science inventions," Working Papers on Innovation Studies 20161209, Centre for Technology, Innovation and Culture, University of Oslo.
    7. Bryn Lander, 2013. "Sectoral collaboration in biomedical research and development," Scientometrics, Springer;Akadémiai Kiadó, vol. 94(1), pages 343-357, January.
    8. María Bordons & Javier Aparicio & Rodrigo Costas, 2013. "Heterogeneity of collaboration and its relationship with research impact in a biomedical field," Scientometrics, Springer;Akadémiai Kiadó, vol. 96(2), pages 443-466, August.
    9. Yeon Hak Kim & Aaron D. Levine & Eric J. Nehl & John P. Walsh, 2020. "A bibliometric measure of translational science," Scientometrics, Springer;Akadémiai Kiadó, vol. 125(3), pages 2349-2382, December.
    10. Anckaert, Paul-Emmanuel & Cassiman, David & Cassiman, Bruno, 2020. "Fostering practice-oriented and use-inspired science in biomedical research," Research Policy, Elsevier, vol. 49(2).
    11. Jordi Molas-Gallart & Pablo D’Este & Oscar Llopis & Ismael Rafols, 2016. "Towards an alternative framework for the evaluation of translational research initiatives," Research Evaluation, Oxford University Press, vol. 25(3), pages 235-243.
    12. French, Catherine E. & Ferlie, Ewan & Fulop, Naomi J., 2014. "The international spread of Academic Health Science Centres: A scoping review and the case of policy transfer to England," Health Policy, Elsevier, vol. 117(3), pages 382-391.
    13. Ha, Kyoo-Man, 2019. "Integrating the resources of Korean disaster management research via the Johari window," Evaluation and Program Planning, Elsevier, vol. 77(C).
    14. Taran Thune & Magnus Gulbrandsen, 2016. "Innovation in hospitals: piloting a tool for investigating contributions of hospital employees to innovation," Working Papers on Innovation Studies 20161211, Centre for Technology, Innovation and Culture, University of Oslo.
    15. French, Martin & Miller, Fiona Alice, 2012. "Leveraging the “living laboratory”: On the emergence of the entrepreneurial hospital," Social Science & Medicine, Elsevier, vol. 75(4), pages 717-724.
    16. Thune, Taran & Mina, Andrea, 2016. "Hospitals as innovators in the health-care system: A literature review and research agenda," Research Policy, Elsevier, vol. 45(8), pages 1545-1557.
    17. Victor J. Krawczyk & Monica A. Hamilton-Bruce & Simon A. Koblar & Jonathan Crichton, 2014. "Group Organization and Communities of Practice in Translational Research," SAGE Open, , vol. 4(4), pages 21582440145, December.
    18. Faatiema Salie & Kylie Jager & Carsten Dreher & Tania S. Douglas, 2019. "The scientific base for orthopaedic device development in South Africa: spatial and sectoral evolution of knowledge development," Scientometrics, Springer;Akadémiai Kiadó, vol. 119(1), pages 31-54, April.
    19. Llopis, Oscar & D’Este, Pablo, 2016. "Beneficiary contact and innovation: The relation between contact with patients and medical innovation under different institutional logics," Research Policy, Elsevier, vol. 45(8), pages 1512-1523.
    20. Dixi Louise Strand, 2020. "Everyday characterizations of translational research: researchers’ own use of terminology and models in medical research and practice," Palgrave Communications, Palgrave Macmillan, vol. 6(1), pages 1-10, December.

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