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Infrastructuring precision medicine: Making gene therapies for rare diseases workable in practice

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  • Wadmann, Sarah
  • Johansen, Anna Brueckner
  • Born, Alfred Peter
  • Kessel, Line

Abstract

Long viewed by social scientists as a future imaginary, precision medicine is now materializing in many healthcare systems in the form of new diagnostic practices and novel treatment modalities, such as gene therapies. Based on an ethnographic study of the introduction of the first two clinically available in-vivo gene therapies in the Danish healthcare system, we investigate what it takes to make these therapies workable in practice. Drawing on social science literature on infrastructuring, we describe the many forms of mundane work required to fit these therapies into regulatory frameworks, political processes and daily work practices in the healthcare system. Further, we observe how the processes of infrastructuring required to introduce the gene therapies into clinical practice had transformative implications as they redistributed roles and responsibilities among clinicians, pharmacists, procurement agencies and pharmaceutical manufacturers.

Suggested Citation

  • Wadmann, Sarah & Johansen, Anna Brueckner & Born, Alfred Peter & Kessel, Line, 2024. "Infrastructuring precision medicine: Making gene therapies for rare diseases workable in practice," Social Science & Medicine, Elsevier, vol. 351(C).
    • Handle: RePEc:eee:socmed:v:351:y:2024:i:c:s0277953624004106
    DOI: 10.1016/j.socscimed.2024.116966
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    2. Susan Leigh Star & Karen Ruhleder, 1996. "Steps Toward an Ecology of Infrastructure: Design and Access for Large Information Spaces," Information Systems Research, INFORMS, vol. 7(1), pages 111-134, March.
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