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Accrual to cancer clinical trials: Directions from the research literature

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  • Gotay, Carolyn Cook

Abstract

Although randomized clinical trials are the predominant method used to evaluate cancer therapies, only a small proportion of potential participants actually enter onto trials. This paper analyzes the research literature on accrual to cancer therapy trials. The research shows that nonparticipation is influenced by physician and patient variables, as well as by characteristics of the specific protocols. Trials design, especially pre-existing treatment preferences, pose significant problems for physicians and patients. Intervention strategies have focused on alternate trial designs, improving the informed consent process, and increasing knowledge about trials. Additional research should focus on the perspectives of patients who accept and decline trial participation and on interventions designed to affect accrual. Future studies need to be sensitive to patient quality of life considerations as well as practical and ethical issues.

Suggested Citation

  • Gotay, Carolyn Cook, 1991. "Accrual to cancer clinical trials: Directions from the research literature," Social Science & Medicine, Elsevier, vol. 33(5), pages 569-577, January.
    • Handle: RePEc:eee:socmed:v:33:y:1991:i:5:p:569-577
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    Cited by:

    1. Verheggen, Frank W. S. M. & van Wijmen, Frans C. B., 1996. "Informed consent in clinical trials," Health Policy, Elsevier, vol. 36(2), pages 131-153, May.
    2. Clairice T. Veit, 2004. "A Single Mathematical Model Predicts Physicians’ Recommendations and Postmenopausal Women’s Decisions to Participate in a Clinical Trial to Prevent Breast Cancer or Coronary Heart Disease," Medical Decision Making, , vol. 24(4), pages 330-350, August.
    3. Heather J. Sutherland & Raquel da Cunha & Gina A. Lockwood & James E. Till, 1998. "What Attitudes and Beliefs Underlie Patients' Decisions about Participating in Chemotherapy Trials?," Medical Decision Making, , vol. 18(1), pages 61-69, January.

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