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Imperfect biomarkers for adjuvant chemotherapy in early stage breast cancer with good prognosis

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  • Bourgain, Catherine
  • Pourtau, Lionel
  • Mazouni, Chafika
  • Bungener, Martine
  • Bonastre, et Julia

Abstract

The proliferation of biomarkers has raised concerns regarding the possibility for clinical judgment to be improperly removed from clinician's jurisdiction and included in laboratory tests. To evaluate the ways in which the diffusion of biomarkers questions the autonomy of clinicians, we consider the case of chemotherapy prescription to women with early stage breast cancer and a good prognosis. Drawing on a qualitative study of clinicians working in a diversity of institutional contexts, we follow three biomarkers available to guide this routinely made decision.

Suggested Citation

  • Bourgain, Catherine & Pourtau, Lionel & Mazouni, Chafika & Bungener, Martine & Bonastre, et Julia, 2020. "Imperfect biomarkers for adjuvant chemotherapy in early stage breast cancer with good prognosis," Social Science & Medicine, Elsevier, vol. 246(C).
    • Handle: RePEc:eee:socmed:v:246:y:2020:i:c:s0277953619307300
    DOI: 10.1016/j.socscimed.2019.112735
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    4. Bourret, Pascale & Keating, Peter & Cambrosio, Alberto, 2011. "Regulating diagnosis in post-genomic medicine: Re-aligning clinical judgment?," Social Science & Medicine, Elsevier, vol. 73(6), pages 816-824, September.
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    1. Ross, Emily & Swallow, Julia & Kerr, Anne & Chekar, Choon Key & Cunningham-Burley, Sarah, 2021. "Diagnostic layering: Patient accounts of breast cancer classification in the molecular era," Social Science & Medicine, Elsevier, vol. 278(C).

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