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A preliminary report on anti-depressant therapy and its effects on hope and immunity

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  • Udelman, Donna Lou
  • Udelman, Harold D.

Abstract

Psychological states such as bereavement and depression have been associated with suppression of the immune response. The authors present a pilot study utilizing the anti-depressant, maprotiline hydrochloride (Ludiomil) to determine its effects on the mental depression and immune reactions of T & B lymphocytes in patients with neurotic depression (dysthymic disorder by DSM III). Hope scores, derived from the content analysis of verbal samples, and Beck depression scores were examined as they covaried with various indices of immune response before and 3 months after the patients were administered either maprotiline or no anti-depressant medication. Although the study did not provide definitive findings regarding improved immune response following treatment of depressed patients with maprotiline hydrochloride, it did suggest further avenues of research for investigation.

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  • Udelman, Donna Lou & Udelman, Harold D., 1985. "A preliminary report on anti-depressant therapy and its effects on hope and immunity," Social Science & Medicine, Elsevier, vol. 20(10), pages 1069-1072, January.
    • Handle: RePEc:eee:socmed:v:20:y:1985:i:10:p:1069-1072
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    Cited by:

    1. Schrank, Beate & Bird, Victoria & Rudnick, Abraham & Slade, Mike, 2012. "Determinants, self-management strategies and interventions for hope in people with mental disorders: Systematic search and narrative review," Social Science & Medicine, Elsevier, vol. 74(4), pages 554-564.

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