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Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals

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  • Bugg, Timothy D.H.
  • Williamson, James J.
  • Alberti, Fabrizio

Abstract

This review discusses the use of engineered microbes for bioconversion of lignin from plant biomass to produce renewable chemicals. Existing bacterial hosts for lignin bioconversion are discussed, such as Pseudomonas putida KT2440 and Rhodococcus jostii RHA1, and case studies where they have been engineered to generate aromatic and non-aromatic products are described, and the different types of lignin substrates used for these studies. Other bacteria identified as lignin degraders are described, and the prospects for using other bacteria as hosts for metabolic engineering of lignin degradation are discussed. Recent advances in genetic modification of fungi are also discussed, which could lead to the metabolic engineering of lignin-degrading fungi for bioproduct formation from lignin. Prospects and challenges in this field are discussed, as the field moves from the laboratory to industrial application, including: choice of chassis organism, choice of lignin feedstock, the complexity of polymeric lignin breakdown, and considerations for scale-up and choice of bioproduct.

Suggested Citation

  • Bugg, Timothy D.H. & Williamson, James J. & Alberti, Fabrizio, 2021. "Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals," Renewable and Sustainable Energy Reviews, Elsevier, vol. 152(C).
    • Handle: RePEc:eee:rensus:v:152:y:2021:i:c:s1364032121009485
    DOI: 10.1016/j.rser.2021.111674
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    References listed on IDEAS

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    1. Patricia Calero & Daniel C. Volke & Phillip T. Lowe & Charlotte H. Gotfredsen & David O’Hagan & Pablo I. Nikel, 2020. "A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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    Cited by:

    1. Liu, Ruo-Ying & Lan, Hai-Na & Liu, Zhi-Hua & Li, Bing-Zhi & Yuan, Ying-Jin, 2024. "Microbial valorization of lignin toward coumarins: Challenges and perspectives," Renewable and Sustainable Energy Reviews, Elsevier, vol. 191(C).
    2. Rubén Agregán & José M. Lorenzo & Manoj Kumar & Mohammad Ali Shariati & Muhammad Usman Khan & Abid Sarwar & Muhammad Sultan & Maksim Rebezov & Muhammad Usman, 2022. "Anaerobic Digestion of Lignocellulose Components: Challenges and Novel Approaches," Energies, MDPI, vol. 15(22), pages 1-24, November.

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