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Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility

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  • Bois, Alex
  • Garcia-Roger, Eduardo M.
  • Hong, Elim
  • Hutzler, Stefan
  • Irannezhad, Ali
  • Mannioui, Abdelkrim
  • Richmond, Peter
  • Roehner, Bertrand M.
  • Tronche, Stéphane

Abstract

Genetic and environmental factors are traditionally seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random “manufacturing” discrepancies with respect to “design” values. A clear way to demonstrate the existence of this component is to “turn off” the two others and to see whether or not there is still remaining variability. Perfect clones raised under well controlled laboratory conditions fulfill the conditions for such a test. Carried out for four different species, the test reveals a variability remainder of the order of 15% in terms of coefficient of variation (i.e. ratio of standard deviation to average, subsequently denoted by CV). As an example, the CV of the volume of E. coli (Escherichia Coli) bacteria immediately after binary fission is of that order.

Suggested Citation

  • Bois, Alex & Garcia-Roger, Eduardo M. & Hong, Elim & Hutzler, Stefan & Irannezhad, Ali & Mannioui, Abdelkrim & Richmond, Peter & Roehner, Bertrand M. & Tronche, Stéphane, 2020. "Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 537(C).
    • Handle: RePEc:eee:phsmap:v:537:y:2020:i:c:s0378437119315596
    DOI: 10.1016/j.physa.2019.122742
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    References listed on IDEAS

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    1. Berrut, Sylvie & Pouillard, Violette & Richmond, Peter & Roehner, Bertrand M., 2016. "Deciphering infant mortality," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 463(C), pages 400-426.
    2. Bois, Alex & Garcia-Roger, Eduardo M. & Hong, Elim & Hutzler, Stefan & Irannezhad, Ali & Mannioui, Abdelkrim & Richmond, Peter & Roehner, Bertrand M. & Tronche, Stéphane, 2019. "Infant mortality across species. A global probe of congenital abnormalities," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 535(C).
    3. Berrut, Sylvie & Richmond, Peter & Roehner, Bertrand M., 2017. "Age spectrometry of infant death rates as a probe of immunity: Identification of two peaks due to viral and bacterial diseases respectively," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 486(C), pages 915-924.
    4. Richmond, Peter & Roehner, Bertrand M., 2016. "Predictive implications of Gompertz’s law," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 447(C), pages 446-454.
    Full references (including those not matched with items on IDEAS)

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