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Evolution of the ubiquitin-activating enzyme Uba1 (E1)

Author

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  • Allan, Douglas C.
  • Phillips, J.C.

Abstract

Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is >14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences.

Suggested Citation

  • Allan, Douglas C. & Phillips, J.C., 2017. "Evolution of the ubiquitin-activating enzyme Uba1 (E1)," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 483(C), pages 456-461.
    • Handle: RePEc:eee:phsmap:v:483:y:2017:i:c:p:456-461
    DOI: 10.1016/j.physa.2017.04.144
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    References listed on IDEAS

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    1. Sachdeva, Vedant & Phillips, James C., 2016. "Oxygen channels and fractal wave–particle duality in the evolution of myoglobin and neuroglobin," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 463(C), pages 1-11.
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    Cited by:

    1. Phillips, J.C., 2021. "Synchronized attachment and the Darwinian evolution of coronaviruses CoV-1 and CoV-2," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 581(C).
    2. Moret, M.A. & Zebende, G.F. & Phillips, J.C., 2019. "Hydropathic wave ordering of alpha crystallin—Membrane interactions enhances human lens transparency and resists cataracts," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 514(C), pages 573-579.

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