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Asynchronous motion and transport of K+ in the KcsA selectivity filter

Author

Listed:
  • Pawełek, K.
  • Kozak, John J.
  • Grzywna, Z.J.

Abstract

A recently proposed Markovian model of K+ ion transport through the selectivity filter of the KcsA bacterial channel is generalized. This generalization allows a specific estimate to be made of the current through the channel which is found to be consistent with experimentally determined values [11.0 (+/−) 0.1 pA]. A further aspect of the generalization presented here is the quantification of the difference of synchronous vs. asynchronous motion of the K+ ions and water molecules in the channel. Considering excluded volume effects only, the difference in mean passage time through the channel is in the range 50%–75%; on the basis of calculations reported here, we argue that this difference will be even more pronounced when K+/ K+ Coulombic repulsions and electrostatic attractive interactions between K+ ions and the carbonyl groups lining the channel are taken into account.

Suggested Citation

  • Pawełek, K. & Kozak, John J. & Grzywna, Z.J., 2010. "Asynchronous motion and transport of K+ in the KcsA selectivity filter," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(16), pages 3013-3022.
    • Handle: RePEc:eee:phsmap:v:389:y:2010:i:16:p:3013-3022
    DOI: 10.1016/j.physa.2010.03.046
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    Cited by:

    1. Ramírez-Piscina, L. & Sancho, J.M., 2018. "Periodic spiking by a pair of ionic channels," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 505(C), pages 345-354.

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