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Dynamics of DNA: Experimental controversies and theoretical insights

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  • Hinczewski, Michael
  • Netz, Roland R.

Abstract

Recent experimental advances using fluorescence correlation spectroscopy (FCS) have given unprecedented information about the small-scale kinetics of large biopolymers in solution. However some of the first studies in this direction yielded conflicting results for the mean squared displacement of the tagged end-point of a DNA chain, deviating from traditional theories of polymer dynamics. Spurred by this controversy, we have developed a hydrodynamic mean-field theory for single semiflexible polymers which points to a resolution of the differing experimental observations. The theory precisely captures, without fitting parameters, one set of recent FCS results, reproducing the experimental dynamics over five decades in time and three decades of chain lengths. The success of the theory makes it an excellent candidate for a variety of biophysical contexts where the internal fluctuations of semiflexible polymers play a role.

Suggested Citation

  • Hinczewski, Michael & Netz, Roland R., 2010. "Dynamics of DNA: Experimental controversies and theoretical insights," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(15), pages 2993-2996.
    • Handle: RePEc:eee:phsmap:v:389:y:2010:i:15:p:2993-2996
    DOI: 10.1016/j.physa.2010.02.012
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    Cited by:

    1. Chi, Qingjia & Wang, Guixue & Jiang, Jiahuan, 2013. "The persistence length and length per base of single-stranded DNA obtained from fluorescence correlation spectroscopy measurements using mean field theory," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(5), pages 1072-1079.

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    Keywords

    DNA;

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