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Modeling subspecies and the tumor-immune system interaction: Steps toward understanding therapy

Author

Listed:
  • Menchón, S.A.
  • Ramos, R.A.
  • Condat, C.A.

Abstract

A mesoscopic nutrient competition model for cancer growth is generalized to describe the growth of a heterogeneous tumor and the interactions between the tumor and the immune system. Our simulations show that the success of a mutation depends not only on its intrinsic competitive advantages, but also on its location in the tumor mass. It is also shown that the simple killing of tumor cells by immune cells, even when their activity is increased by therapy, is not sufficient to stem tumor growth, but another mechanism (such as pinning) is needed for a successful therapy.

Suggested Citation

  • Menchón, S.A. & Ramos, R.A. & Condat, C.A., 2007. "Modeling subspecies and the tumor-immune system interaction: Steps toward understanding therapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 386(2), pages 713-719.
    • Handle: RePEc:eee:phsmap:v:386:y:2007:i:2:p:713-719
    DOI: 10.1016/j.physa.2007.07.010
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    Cited by:

    1. El-Gohary, Awad & Alwasel, I.A., 2009. "The chaos and optimal control of cancer model with complete unknown parameters," Chaos, Solitons & Fractals, Elsevier, vol. 42(5), pages 2865-2874.

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    Keywords

    Tumor; Subspecies; Immunotherapy;
    All these keywords.

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