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Correlations in the T-cell response to altered peptide ligands

Author

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  • Park, Jeong-Man
  • Deem, Michael W.

Abstract

The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of pre-existing T-cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T-cell immune responses. The nonlinear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level diversity of the T-cell repertoire drives the dynamics of the immune response against mutated viral antigens.

Suggested Citation

  • Park, Jeong-Man & Deem, Michael W., 2004. "Correlations in the T-cell response to altered peptide ligands," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 341(C), pages 455-470.
    • Handle: RePEc:eee:phsmap:v:341:y:2004:i:c:p:455-470
    DOI: 10.1016/j.physa.2004.04.127
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    References listed on IDEAS

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    1. Paul Klenerman & Rolf M. Zinkernagel, 1998. "Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes," Nature, Nature, vol. 394(6692), pages 482-485, July.
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    Cited by:

    1. Yang, Ming & Park, Jeong-Man & Deem, Michael W., 2006. "A theory of multi-site vaccination for cancer," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 366(C), pages 347-364.

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