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Model of unequal chromosomal crossing over in DNA sequences11This work is supported by NIH-HGP

Author

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  • Dokholyan, Nikolay V.
  • Buldyrev, Sergey V.
  • Havlin, Shlomo
  • Stanley, H.Eugene

Abstract

It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ=2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

Suggested Citation

  • Dokholyan, Nikolay V. & Buldyrev, Sergey V. & Havlin, Shlomo & Stanley, H.Eugene, 1998. "Model of unequal chromosomal crossing over in DNA sequences11This work is supported by NIH-HGP," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 249(1), pages 594-599.
    • Handle: RePEc:eee:phsmap:v:249:y:1998:i:1:p:594-599
    DOI: 10.1016/S0378-4371(97)00520-7
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    Cited by:

    1. Zhang, Linxi & Sun, Tingting, 2005. "Statistical properties of nucleotides in human chromosomes 21 and 22," Chaos, Solitons & Fractals, Elsevier, vol. 23(3), pages 1077-1085.
    2. Buldyrev, Sergey V. & Dokholyan, Nikolay V. & Havlin, Shlomo & Stanley, H.Eugene & Stanley, Rachel H.R., 1999. "Expansion of tandem repeats and oligomer clustering in coding and noncoding DNA sequences," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 273(1), pages 19-32.

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    Keywords

    DNA; Mutations; Repeats;
    All these keywords.

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