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Statistical physics and Alzheimer’s disease

Author

Listed:
  • Stanley, H.Eugene
  • Buldyrev, Sergey V
  • Cruz, Luis
  • Gomez-Isla, Teresa
  • Havlin, Shlomo
  • Hyman, Bradley T
  • Knowles, Roger
  • Urbanc, Brigita
  • Wyart, Claire

Abstract

We discuss the possible utility of statistical physics in elucidating some of the puzzling phenomena that seem to occur in the brains of patients affected with Alzheimer’s disease. Further, we report three specific results from this approach: (i) The size distribution of senile plaques appears to be log-normal, (ii) We develop a model for growth of senile plaques that is characterized by both aggregation and disaggregation, and (iii) We quantify neuron architecture and find quantitative evidence for the existence of microcolumns positioned at right angles to the known lamina.

Suggested Citation

  • Stanley, H.Eugene & Buldyrev, Sergey V & Cruz, Luis & Gomez-Isla, Teresa & Havlin, Shlomo & Hyman, Bradley T & Knowles, Roger & Urbanc, Brigita & Wyart, Claire, 1998. "Statistical physics and Alzheimer’s disease," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 249(1), pages 460-471.
    • Handle: RePEc:eee:phsmap:v:249:y:1998:i:1:p:460-471
    DOI: 10.1016/S0378-4371(97)00548-7
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    Cited by:

    1. Slanina, Frantisek, 2013. "Essentials of Econophysics Modelling," OUP Catalogue, Oxford University Press, number 9780199299683.
    2. Stanley, H.Eugene, 2000. "Exotic statistical physics: Applications to biology, medicine, and economics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 285(1), pages 1-17.

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