IDEAS home Printed from https://ideas.repec.org/a/eee/matcom/v40y1995i1p35-69.html
   My bibliography  Save this article

A computational model of spindle oscillations

Author

Listed:
  • Thomas, Elizabeth
  • Wyatt, Robert E.

Abstract

A model of the thalamocortical system was constructed for the purpose of a computational analysis of spindle. The parameters used in the model were based on experimental measurements. The model included a reticular thalamic nucleus and a dorsal layer. The thalamic cells were capable of undergoing a low threshold Ca2+ mediated spike. The simulation was used to investigate the plausibility an ramifications of certain proposals that have been put forward for the production of spindle. An initial stimulus to the model reticular thalamic layer was found to give rise to activity resembling spindle. The emergent population oscillations were analyzed for factors that affected its frequency and amplitude. The role of cortical feedback to the pacemaking RE layer was also investigated. Finally, a non-linear dynamics analysis was conducted on the emergent population oscillations. This activity was found to yield a positive Lyapunov exponent and define and attractor of low dimensions. Excitatory feedback was found to decrease the dimensionality of the attractor at the reticular thalamic layer.

Suggested Citation

  • Thomas, Elizabeth & Wyatt, Robert E., 1995. "A computational model of spindle oscillations," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 40(1), pages 35-69.
    • Handle: RePEc:eee:matcom:v:40:y:1995:i:1:p:35-69
    DOI: 10.1016/0378-4754(95)00017-6
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/0378475495000176
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/0378-4754(95)00017-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:matcom:v:40:y:1995:i:1:p:35-69. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/mathematics-and-computers-in-simulation/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.