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Development of control strategies for high cell density cultivations

Author

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  • Luttmann, Reiner
  • Bitzer, Gerhard
  • Hartkopf, Jens

Abstract

The high cell density cultivation (HCDC) of genetically modified microorganisms, e.g. E. coli, with dry weight larger than 100 g⧸l, requires fed-batch processing with aid of a controlled specific growth rate μ. A general mathematical model of HCDC as well as different methods to control μ is discussed. Furthermore, the implementation of control strategies in an industrial process control system is shortly explained. The test of the control equipment is carried out with by means of on-line simulation methods. The comparison of theoretical investigations with an experimental verification of a high cell density E. coli cultivation demonstrates the the usefulness of our methods.

Suggested Citation

  • Luttmann, Reiner & Bitzer, Gerhard & Hartkopf, Jens, 1994. "Development of control strategies for high cell density cultivations," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 37(2), pages 153-164.
    • Handle: RePEc:eee:matcom:v:37:y:1994:i:2:p:153-164
    DOI: 10.1016/0378-4754(94)00004-2
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