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Calculating an intervention's (cost-)effectiveness for the real-world target population: The potential of combining strengths of both RCTs and observational data

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  • Neyt, Mattias
  • Cleemput, Irina
  • Thiry, Nancy
  • De Laet, Chris

Abstract

Economic evaluations most often use results from randomised controlled trials (RCTs) to model effectiveness. Inconsiderate application of the absolute treatment effect from RCTs may result in unrealistic estimates of an intervention's benefit for the real-world target population. The baseline risk of events in this target population may differ significantly from the baseline risk in the RCT population.

Suggested Citation

  • Neyt, Mattias & Cleemput, Irina & Thiry, Nancy & De Laet, Chris, 2012. "Calculating an intervention's (cost-)effectiveness for the real-world target population: The potential of combining strengths of both RCTs and observational data," Health Policy, Elsevier, vol. 106(2), pages 207-210.
    • Handle: RePEc:eee:hepoli:v:106:y:2012:i:2:p:207-210
    DOI: 10.1016/j.healthpol.2012.04.014
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    References listed on IDEAS

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    1. Drummond, Michael F. & Sculpher, Mark J. & Torrance, George W. & O'Brien, Bernie J. & Stoddart, Greg L., 2005. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 3, number 9780198529453.
    2. Mattias Neyt & Chris Laet & Annemieke Ridder & Hans Brabandt, 2009. "Cost Effectiveness of Drug-Eluting Stents In Belgian Practice," PharmacoEconomics, Springer, vol. 27(4), pages 313-327, April.
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    Cited by:

    1. M. Campioni & I. Agirrezabal & R. Hajek & J. Minarik & L. Pour & I. Spicka & S. Gonzalez-McQuire & P. Jandova & V. Maisnar, 2020. "Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(2), pages 219-233, March.

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