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AFM imaging, fractal analysis and in vitro cytotoxicity evaluation of Zn(II) vs. Cu(II) porphyrins

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  • Socoteanu, Radu
  • Anastasescu, Mihai
  • Dobrescu, Gianina
  • Boscencu, Rica
  • Vasiliu, Georgiana
  • Constantin, Carolina

Abstract

A pair of unsymmetrical porphyrinic complexes with Cu(II) and Zn(II) as metallic ion are studied first time by a combination of atomic force microscopy experiments with complex fractal analysis. In view of a possible use of these metalloporphyrins in diagnosis and photodynamic therapy of cancer, the morphological and structural investigations were coupled with cytotoxicity evaluation using U937 cell line. Atomic force microscopy coupled with fractal analysis was proved to be a useful tool to predict the self-similarity domains, in terms of morphology patterns with specific fractal dimensions which may be used to predict a better bio-activity in potential medial applications.

Suggested Citation

  • Socoteanu, Radu & Anastasescu, Mihai & Dobrescu, Gianina & Boscencu, Rica & Vasiliu, Georgiana & Constantin, Carolina, 2015. "AFM imaging, fractal analysis and in vitro cytotoxicity evaluation of Zn(II) vs. Cu(II) porphyrins," Chaos, Solitons & Fractals, Elsevier, vol. 77(C), pages 304-309.
    • Handle: RePEc:eee:chsofr:v:77:y:2015:i:c:p:304-309
    DOI: 10.1016/j.chaos.2015.06.013
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    1. Family, Fereydoon, 1990. "Dynamic scaling and phase transitions in interface growth," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 168(1), pages 561-580.
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    Keywords

    Metalloporphyrins; AFM; Fractal analysis; U937 cell line; PDT;
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