IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v71y2015icp46-54.html
   My bibliography  Save this article

Maximum therapeutic effect of glioma treatment by radio-frequency electric field

Author

Listed:
  • Iomin, Alexander

Abstract

The influence of a radio-frequency electric field on glioma brain cancer development is considered. Specifically, the effectiveness of this medical technology against invasive cells with a high motility, when switching between migrating and proliferating phenotypes takes place, is addressed. It is shown that glioma development under the external field treatment can be modeled in the framework of the continuous time random walk, where the segregation of proliferating from not proliferating cells by the external electric field is naturally accounted for. The constructed reaction-transport equation is based on the fact that cytokinesis affects the cell dynamics strongly, and the cell kinetics is non-Markovian, which is reflected in both the transport and reaction properties of cells. As a result of the interplay between cell proliferation and cell degradation, migrating cancer cells spread freely without being influenced by the details of the degradation of the proliferating cells, which leads to a decrease in the effectiveness of the treatment.

Suggested Citation

  • Iomin, Alexander, 2015. "Maximum therapeutic effect of glioma treatment by radio-frequency electric field," Chaos, Solitons & Fractals, Elsevier, vol. 71(C), pages 46-54.
    • Handle: RePEc:eee:chsofr:v:71:y:2015:i:c:p:46-54
    DOI: 10.1016/j.chaos.2014.11.020
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077914002100
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2014.11.020?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:71:y:2015:i:c:p:46-54. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.