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Tumor evasion from immune control: Strategies of a MISS to become a MASS

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  • d’Onofrio, Alberto

Abstract

We biologically describe the phenomenon of the evasion of tumors from immune surveillance where tumor cells, initially constrained to exist in a microscopic steady state (MISS) elaborate strategies to evade from the immune control and to reach a macroscopic steady state (MASS). We, then, describe “evasion” as a long term loss of equilibrium in a framework of prey–predator-like models with adiabatic varying parameters, whose changes reflect the evolutionary adaptation of the tumor in a “hostile” environment by means of the elaboration of new strategies of survival. Similarities and differences between the present work and the interesting seminal paper [Kuznetsov VA, Knott GD. Modeling tumor regrowth and immunotherapy. Math Comput Model 2001;33:1275–87] are discussed. We also propose and study a model of clonal resistance to the immune control with slowly varying adaptive mutation parameter.

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  • d’Onofrio, Alberto, 2007. "Tumor evasion from immune control: Strategies of a MISS to become a MASS," Chaos, Solitons & Fractals, Elsevier, vol. 31(2), pages 261-268.
    • Handle: RePEc:eee:chsofr:v:31:y:2007:i:2:p:261-268
    DOI: 10.1016/j.chaos.2005.10.006
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