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Obesity and Alzheimer’s: An attempt to decipher the role of obesity in blood–brain barrier degradation

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  • Jain, Ani
  • Roy, Parimita

Abstract

The effects of obesity on memory and cognitive function have been reported, which could further lead to Alzheimer’s disease (AD). Observational studies have found both a negative and a positive association between body shape and AD. For this purpose, we designed a diffusive obesity–Alzheimer’s model consisting of fat cells, glucose, insulin, beta cells, cytokines, microglia, Aβ plaques, and neurofibrillary tangles. We have shown the developed model’s global existence, non-negativity, and long-term behavior. Additionally, equilibrium points for the ODE are analyzed for existence and stability. We adopted the Partial Rank Correlation Coefficient (PRCC) to conduct a global sensitivity analysis to estimate the most sensitive parameters responsible for Aβ and τ plaque progression. We provided a complete numerical analysis based on our deterministic and diffusive models. A patchy pattern is typically formed in mathematical simulations of spatially explicit systems, reflecting complicated spatiotemporal dynamics. This work suggests that insulin resistance and pro-inflammatory microglia may be responsible for obesity-associated cognitive decline.

Suggested Citation

  • Jain, Ani & Roy, Parimita, 2023. "Obesity and Alzheimer’s: An attempt to decipher the role of obesity in blood–brain barrier degradation," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).
    • Handle: RePEc:eee:chsofr:v:166:y:2023:i:c:s0960077922010815
    DOI: 10.1016/j.chaos.2022.112902
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    References listed on IDEAS

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    1. Ishwar K Puri & Liwu Li, 2010. "Mathematical Modeling for the Pathogenesis of Alzheimer's Disease," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-5, December.
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