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Long-term exposure to polycyclic musk tonalide - A potential threat to juvenile zebrafish (Danio rerio)?

Author

Listed:
  • J Cahova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • J Blahova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • L Plhalova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • P Marsalek

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • V Doubkova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • M Hostovsky

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • L Divisova

    (Simulation Centre, Faculty of Medicine, Masaryk University, Brno, Czech Republic)

  • J Mares

    (Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of Agrosciences, Mendel University Brno, Brno, Czech Republic)

  • C Faggio

    (Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy)

  • Z Svobodova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

Abstract

Polycyclic musk compounds are commonly used in personal care products to replace expensive natural fragrances. Due to their huge consumption, they have become a part of the aquatic environment. In the present study, a two-month exposure effect of tonalide on juvenile zebrafish (Danio rerio) was investigated. We determined the vitellogenin concentration to define the potential endocrine-disrupting effect of tonalide and also analysed selected indices to evaluate the induction of oxidative stress. The environmentally relevant concentration of tonalide (i.e., 500 ng/l) caused a significant decrease in the catalase activity (P < 0.05) and a significant increase (P < 0.05) in the lipid peroxidation. An increasing lipid peroxidation was also recorded for the highest concentration group tested (i.e., 50 000 ng/l). On the other hand, no significant changes were recorded in vitellogenin in all the exposed groups. Thus, based on these results, we have not demonstrated the endocrine-disrupting activity of tonalide in zebrafish. The results of the oxidative stress indices showed a significant impairment of the antioxidant defence after the two-month tonalide exposure, which could indicate part of the adaptive response to the tonalide toxicity.

Suggested Citation

  • J Cahova & J Blahova & L Plhalova & P Marsalek & V Doubkova & M Hostovsky & L Divisova & J Mares & C Faggio & Z Svobodova, 2023. "Long-term exposure to polycyclic musk tonalide - A potential threat to juvenile zebrafish (Danio rerio)?," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 68(5), pages 218-224.
    • Handle: RePEc:caa:jnlvet:v:68:y:2023:i:5:id:40-2023-vetmed
    DOI: 10.17221/40/2023-VETMED
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    Cited by:

    1. J Blahova & P Mikula & P Marsalek & Z Svobodova, 2025. "Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 70(1), pages 20-29.

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