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Apocrine cystomatosis: From the aspect of epithelial-mesenchymal transition

Author

Listed:
  • TU Kim

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • SW Lee

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • SM Baek

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • JH Yim

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • YJ Lee

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • JH Son

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • SJ Park

    (Laboratory of Veterinary Histology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

  • JK Park

    (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea)

Abstract

Apocrine cystomatosis, also called epitrichial sweat gland cystomatosis, is a non-neoplastic condition characterised by multiple dilated cysts of sweat gland origin. Histopathologically, these cysts comprise two layers of cells: an inner layer of glandular epithelial cells and an outer layer of myoepithelial cells. A case of apocrine cystomatosis was admitted to a local hospital. The microscopic investigation revealed that some enlarged cysts showed the transition of glandular epithelial cells into a spindle, mesenchymal cell-like morphology. The epithelial-to-mesenchymal transition (EMT) has long been studied as a pathway for embryogenesis, organ development, and carcinogenesis. While various molecular factors, including cytokines and growth factors, are known to induce EMT, mechanical forces have also been proposed to initiate EMT. The present case describes a possible relationship between EMT occurring in a cystic condition and further pathological inspection.

Suggested Citation

  • TU Kim & SW Lee & SM Baek & JH Yim & YJ Lee & JH Son & SJ Park & JK Park, 2023. "Apocrine cystomatosis: From the aspect of epithelial-mesenchymal transition," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 68(1), pages 33-37.
    • Handle: RePEc:caa:jnlvet:v:68:y:2023:i:1:id:77-2022-vetmed
    DOI: 10.17221/77/2022-VETMED
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